The effects of Ti and La additions on the microstructures and mechanical properties of B-refined and Sr-modified Al-11Si alloys were investigated in the present work. The interactions among Ti, La, B and Sr elements were discussed employing microstructure observation, thermal analysis and tensile test, respectively. It was found that the addition of 0.05 wt.% B induces a transformation of eutectic Si from finely fibrous to coarsely plate-like morphology in the Al-11Si alloy with 0.02 wt.%Sr modification, owing to the poisoning of IIT mechanism, and the eutectic Si grows only with TPRE mechanism. Both titanium and lathanum can neutralize the co-poisoning effect between Sr and B in the Al-11Si alloy, but the neutralizing effect of La is dependent on the addition sequence. The combinative addition of La and B elements promotes the effective refinement of α-Al grains, but an imhomogeneous modification of eutectic Si phases is also observed, leading to a slightly decrease in the elongation.