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Abstract
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The present study describes a sensitive, eco-friendly and selective electrochemical sensor for quantification of β-carotene (BCA) upon the modification of glassy carbon electrode (GCE) surface with β-cyclodextrin (β-CD)-graphene quantum dots (GQDs). The structural properties, surface morphology and electrochemical characterization of the nanocomposite (β-CD@GQDs) was characterized by TEM, XRD, FTIR, fluorescence, UV and electrochemical impedance spectroscopic methods. Further, the proposed electrochemical sensor exhibited good electrochemical and analytical performance as investigated by CV, SWV and DPV. Under optimized conditions, SWV and DPV were chosen as analytical techniques for quantification of BCA. The proposed electrochemical sensor showed good sensitivity and applicability with linearity range of 0.01 - 71.1 μM and 0.05 - 62.5 μM for SWV and DPV methods having the limit of detection values of 0.008 μM and 0.023 μM, respectively. The designed sensor exhibited good selectivity against some interfering substances. In conclusion, the fabricated sensor, β-CD@GQDs/GCE used for the quantification of BCA in pharmaceutical and fortified biological fluids showed good reproducibility, sensitivity and long-term stability.
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